Adrian Smith

Dr
Adrian
Smith
University Lecturer in Infectious Diseases & Fellow of St Catherine’s College
 

Adrian Smith’s research focuses on understanding the basis of immunity to infection, including the study of immune mechanisms that operate in birds and mammals.

In particular, he is interested in how T lymphocytes contribute to immunity in the gut. The outcomes of this research contribute towards the development of effective immune interventions, such as vaccines. These could be especially valuable in protecting the food supply chain by reducing the impact of infection in livestock (e.g. control of coccidiosis) and preventing the transmission of diseases from livestock to humans including Salmonella, Campylobacter or avian influenza.

Dr Smith also works on the biology of pattern recognition receptors including the Toll-like Receptors which are important in the initial recognition of microbial challenge and the responses generated by adjuvants after vaccination.

Adrian Smith holds Jenner Investigator status in recognition of contributions to vaccine development (www.jenner.ac.uk).

Website
http://www.zoo.ox.ac.uk/staff/academics/smith_al.htm

Recent Relevant Publications: 
  1. Blake, D.P., Oakes R.D and Smith A.L. (2011)  A genetic linkage map for the apicomplexan protozoan parasite Eimeria maxima and comparison with Eimeria tenella. Int J Parasitol 41 263-270
  2. Inagaki-Ohara, K., Sakamoto, V., Dohi, T. and Smith, A.L. (2011). Gamma-delta T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine. Immunology, In press
  3. Blake, D.P., Billington K., Copestake S., Oakes R.D., Quail M.A., Wan, K-L,, Shirley M.W. and Smith A.L. (2011) Genetic mapping identifies novel highly protective antigens for an Apicomplexan parasite. Plos Pathogens, 7 (2) e1001279
  4. Mwangi, W. N., L. P. Smith, Baigent, S.J., Beal, R. K., Nair, V. and Smith, A. L. (2011). Clonal Structure of Rapid-Onset MDV-Driven CD4+ Lymphomas and Responding CD8+ T Cells. PLoS Pathog 7(5): e1001337.
  5. Toscano, MJ, Sait, L, Jorgensen, F, Nicol, C, Powers, C, Smith, A, Bailey, M, and Humphrey TJ (2010) Sub-clinical infection with Salmonella in chickens differentially affects behaviour and welfare in three inbred strains Brit Poul Sci. 51(6), 703-713
  6. Mwangi, M.N., Beal, R.K., Powers, C., Wu, X., Humphrey, T., Watson, M., Bailey, M. Friedman, A., and Smith, A.L. (2010). Regional and global changes in TCRab T cell repertoires in the gut are dependent upon the complexity of the enteric microflora. Dev. Comp. Immunol. 34, 406-417
  7. Blake, D. P., Z. H. Qin, J. P. Cai and A. L. Smith (2008) Development and validation of real-time PCR assays specific to four species of Eimeria. Avian Pathology: 37 (1), 89-94
  8. MacDonald, M.R.W., Xia, J, Smith, A.L. and Magor, K.E. (2008) The duck Toll-like receptor 7: Genomic organization, expression and function. Mol. Immunol. 45 (7); 2055-2061
  9. Beal R.K. and Smith A.L. (2007) The antibody response to Salmonella: its induction and role in protection against avian enteric salmonellosis. Expert reviews in Anti-infective therapy 5: 873-881
  10. Boyd, A., V.J. Philbin and A.L. Smith (2007) Conserved and distinct aspects of the avian Toll-like receptor (TLR) system: implications for transmission and control of bird-borne zoonoses Biochemical Society Transactions (2007) 35: 1504-1507
  11. Shirley, M. W., Smith A. L. and Blake, D.P. (2007) Challenges in the successful control of the avian coccidian. Vaccine; 25 5540-5547
  12. Blake, D. P., M. W. Shirley, and A. L. Smith. (2006) Genetic identification of antigens protective against coccidia. Parasite Immunol 28:305-314.
  13. Blake, D. P., P. Hesketh, A. Archer, M. W. Shirley, and A. L. Smith. (2006) Eimeria maxima: the influence of host genotype on parasite reproduction as revealed by quantitative real-time PCR. Int J Parasitol 36:97-105.
  14. Beal, R. K., C. Powers, T. F. Davison, P. A. Barrow, and A. L. Smith. (2006) Clearance of enteric Salmonella enterica serovar Typhimurium in chickens is independent of B-cell function. Infect Immun 74:1442-1444.
  15. Smith, A.L. (2006) Defining the protective antigen: a long-standing issue for antiparasite vaccine development. Crystal Ball article. Parasite Immunol. 28, 6: 243-244
  16. Kwa, S-F., P. Beverley and A. L. Smith (2006) Peyer’s patches are required for the induction of rapid Th1 responses in the gut and mesenteric lymph nodes during an enteric infection J. Immunol. 176: 7533-7541
  17. Inagaki-Ohara, K.,  F. Nurannisa Dewi, H. Hisaeda, A. L. Smith, F. Jimi, M. Miyahira, A. S. F. Abdel-Aleem, Y. Horii and Y. Nawa (2006) Intestinal intraepithelial lymphocytes sustain the epithelial barrier function against Eimeria vermiformis infection. Infec. Immun. 74:5292-5301 
  18. Beal, R.K., P. Wigley, C. Powers, P.A. Barrow, A.L. Smith (2006) Cross-reactive cellular and humoral immune responses to Salmonella enterica serovars Typhimurium and Enteritidis are associated with protection to heterologous re-challenge. Vet Imm. ImmunoPath; 114:84-93
  19. Iqbal, M., V. J. Philbin, and A. L. Smith. (2005) Expression patterns of chicken Toll-like receptor mRNA in tissues, immune cell subsets and cell lines. Vet Immunol Immunopathol 104:117-27.
  20. Iqbal, M., V. J. Philbin, G. S. Withanage, P. Wigley, R. K. Beal, M. J. Goodchild, P. Barrow, I. McConnell, D. J. Maskell, J. Young, N. Bumstead, Y. Boyd, and A. L. Smith. (2005) Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar Typhimurium. Infect Immun 73:2344-50.
  21. Kogut, M. H., M. Iqbal, H. He, V. Philbin, P. Kaiser, and A.L. Smith (2005) Expression and function of Toll-like receptors in chicken heterophils. Dev Comp Immunol 29:791-807.
  22. Philbin, V. J., M. Iqbal, Y. Boyd, M. J. Goodchild, R. K. Beal, N. Bumstead, J. Young, and A. L. Smith (2005) Identification and characterization of a functional, alternatively spliced Toll-like receptor 7 (TLR7) and genomic disruption of TLR8 in chickens. Immunology 114:507-21.