Fredrik Karpe

Oxford Centre for Diabetes, Endocrinology and Metabolism
University of Oxford
Churchill Hospital

Professor of Metabolic Medicine

Fredrik Karpe's carries out genetic epidemiological research studying human metabolism to understand the complications of obesity and type 2 diabetes.

He initiated the Oxford Biobank for prospective genetic epidemiological research. The aim is to study human lipid and carbohydrate metabolism using integrative physiological and genomic approaches to understand the complications of obesity and type 2 diabetes.

Fredrik is also assessing the metabolic effects of short-term high-fat and high-carbohydrate diets, following changes in gene expression and linking them to alterations in metabolic control. Dr Leanne Hodson, BHF Intermediate Fellow, working in the research group, is also an expert on biomarkers used to monitor dietary fat intake.


Recent Relevant Publications: 

1. Hodson L, Skeaff CM, Fielding BA. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res. 2008 Sep;47(5):348-80.

2. Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA. Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. Am J Physiol Endocrinol Metab. 2009 Jan;296(1):E64-71.

3. Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F. Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab. 2009 May;94(5):1781-8.

4. Karpe F, Dickmann JR, Frayn KN. Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes. 2011 Oct;60(10):2441-9.

5. McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F. Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes. 2011 Jan;60(1):47-55.