Leanne Hodson

leanne.hodson@ocdem.ox.ac.uk

Oxford Centre for Diabetes Endocrinology and Metabolism
University of Oxford
Churchill Hospital
Headington
OX3 7LJ

Themes
Dr
Leanne
Hodson
University Research Lecturer & BHF Intermediate Fellow in Basic Science
 

Leanne studies the hepatic processes in humans, looking at the accumulation of liver fat and diseases associated with this.

The liver is a major player in fat metabolism as it integrates endogenous and exogenous fatty acids (FAs). Perturbations in liver FA metabolism have the potential to impact widely on metabolic health. Leanne is interested in the fatty acid metabolism and their use as biomarkers of dietary intake.

Her work involves the use of stable-isotope tracers to further advance understanding of postprandial hepatic fatty acid metabolism in humans.

Website
http://www.ocdem.ox.ac.uk/grant-holders/researcher/leanne-hodson

Recent Relevant Publications: 
  • Pinnick KE, Neville MJ,  Fielding BA, Frayn KN, Karpe F, Hodson L. Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans. Diabetes 2012;61:1399-1403
  • Bradbury KE, Skeaff CM, Crowe FL, Green TJ, Hodson L. Serum Fatty acid reference ranges:percentiles from a National Nutrition Survey. Nutrients 2011;3: 152-163;doi:10.3390/nu3010152
  • McQuaid SE, Hodson L, Dennis L, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F. Down-regulation of adipose tissue fatty acid trafficking in obesity as a driver for ectopic fat deposition.  Diabetes 2011;60:47-55
  • Hodson L, McQuaid SE, Humphreys  SM, Milne R, Fielding BA, Frayn KN, Karpe F. Greater dietary fatty acid oxidation in abdominally-obese compared to lean men: an adaptive mechanism to prevent liver fat accumulation? Am J Physiol Endocrinol Metab 2010;299:E584-592
  • Hodson L, Harnden KE, Roberts R, Dennis AL, Frayn KN. DASH diet lowers blood pressure without effect on measures of peripheral vascular function.  J Hum Hyper 2010;24:312-319 
  • Ruge T and  Hodson L Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F. Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab 2009;94:1781-1788.
  • Hodson L, McQuaid SE, Karpe F, Frayn KN, Fielding BA. Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate and palmitate. Am J Physiol Endocrinol Metab 2009:296: E64-E71.
  • Hodson L, Skeaff CM, Fielding BA. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 2008;47: 348-80
  • Chong MF-F and Hodson L, Bickerton AS, Roberts R, Neville M, Karpe F, Frayn KN Fielding, BA. Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 days of high-carbohydrate feeding. Am J Clin Nutr 2008;87:817-23.
  • Hodson L, Bickerton AS, McQuaid SE, Roberts R, Karpe F, Frayn KN, Fielding BA. The contribution of splanchnic fat to VLDL triglyceride is greater in insulin-resistant than insulin-sensitive men and women: studies in the postprandial state. Diabetes 2007;56: 2433-41.