Lee Sweetlove


Department of Plant Sciences
University of Oxford
South Parks Road

Reader in Plant Biochemistry

Lee’s research aims to increase our understanding of regulation of flux through plant metabolic networks and to exploit this knowledge for engineering increased yield and quality of crops and for increased production of useful metabolic end-products.

His group uses a variety of biochemical, molecular and modelling approaches to understand metabolic flux at the network level.

Current projects include: a whole-plant metabolic model of resource allocation in Arabidopsis; modelling flavour traits in tomato fruit; intracellular transport of metabolites as a determinant of tomato fruit flavour; and investigation of the metabolic factors influencing carbon-use efficiency.


Recent Relevant Publications: 

Schwärzlander, M., Logan, D.C., Johnston, I.G., Jones, N.S. Fricker, M.D. and Sweetlove, L.J. (2012) Pulsing of membrane potential in individual mitochondria: a stress induced mechanism to regulate respiratory bioenergetics in Arabidopsis. Plant Cell, 24: 1188-1201

Sweetlove, L.J. and Ratcliffe, R.G. (2011) Flux-balance modelling of plant metabolism. Frontiers in Plant Science 2:38. doi: 10.3389/fpls.2011.00038.

Williams, T.C., Poolman, M.G., Howden, A.J., Schwarzlander, M., Fell, D.A., Ratcliffe, R.G., & Sweetlove, L.J. (2010) A genome-scale metabolic model accurately predicts fluxes in central carbon metabolism under stress conditions. Plant Physiol 154, 311-323

Poolman, M.G., Miguet, L. Sweetlove, L.J. & Fell, D.A. (2009) A Genome-scale Metabolic Model of Arabidopsis and some of its properties. Plant Physiol 151, 1570-1581

Sweetlove, L.J., Fell, D.A. & Fernie, A.R. (2008) Getting to grips with the plant metabolic network. Biochem J 409, 27-41

Sweetlove, L.J., Lytovchenko, A., Morgan, M., Nunes-Nesi, A., Taylor, N.L., Baxter, C.J., Eickmeier, I. & Fernie, A.R. (2006) Mitochondrial uncoupling protein is required for efficient photosynthesis. Proc Natl Acad Sci USA 103,19587-19592