Simon Newstead

Department of Biochemistry
University of Oxford
South Parks Road

MRC Career Development Award Research Fellow

Simon’s research focuses on understanding how nutrient transporters in the human body function at a molecular level.

His work on the crystal structure of peptide transporters aims to extend the use of protein crystallography to provide novel insights into the molecular details underpinning peptide and drug recognition within the peptide transporter family.

The hope is that this knowledge will enable improvements in the design and pharmacokinetic properties of drugs for oral administration and open new avenues of investigation into how peptides are distributed within the body.


Recent Relevant Publications: 

1.  Alternating access mechanism in the POT family of oligopeptide transporters.

Solcan N, Kwok J, Fowler PW, Cameron AD, Drew D, Iwata S, Newstead S.

EMBO J. 2012 Jun 1. doi: 10.1038/emboj.2012.157. [Epub ahead of print]

2. Towards a structural understanding of drug and peptide transport within the proton-dependent oligopeptide transporter (POT) family.

Newstead S.

Biochem Soc Trans. 2011 Oct;39(5):1353-8. Review.

3.  Crystal structure of a prokaryotic homologue of the mammalian oligopeptide-proton symporters, PepT1 and PepT2.

Newstead S, Drew D, Cameron AD, Postis VL, Xia X, Fowler PW, Ingram JC, Carpenter EP, Sansom MS, McPherson MJ, Baldwin SA, Iwata S.

EMBO J. 2011 Jan 19;30(2):417-26. Epub 2010 Dec 3.